An Efficient Method for the Chemoselective Synthesis of Acylals from Aromatic Aldehydes Using Bismuth Triflate

Ram S. Mohan, Marc D. Carrigan, Kyle J. Eash, Matthew C. Oswald

Research output: Journal ArticleArticlepeer-review


Aromatic aldehydes are smoothly converted into the corresponding acylals in good yields in the presence of 0.10 mol% Bi(OTf)3•xH2O. Ketones are not affected under the reaction conditions. The highly catalytic nature of bismuth triflate and the fact that it is relatively non-toxic, easy to handle and insensitive to small amounts of air and moisture makes this procedure especially attractive for large-scale synthesis.
Original languageAmerican English
StatePublished - 2001


  • Acylals
  • acylation
  • bismuth and compounds
  • protecting groups.


  • Organic Chemistry

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