Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using Bismuth (III) Bromide

Tyler J. Rauwolf, Zhijia Geng, Jared L. Renfroe, Jack H. Roireau, Lauren T. Yep, Ram S. Mohan

Research output: Journal ArticleArticlepeer-review


An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.
Original languageAmerican English
JournalGreen and Sustainable Chemistry
StatePublished - Jul 18 2019


  • Bismuth
  • Bismuth Bromide
  • Conjugate Addition
  • Green Chemistry
  • Indoles


  • Physics
  • Biological and Chemical Physics

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