Environment Friendly Organic Synthesis Using Bismuth Compounds. An Efficient Method for Carbonyl-ene Reactions Catalyzed by Bismuth Triflate

Ram S. Mohan, Erin D. Anderson, Justin J. Ernat, Mai P. Nguyen, Ann C. Palma

Research output: Journal ArticleArticlepeer-review


Bismuth triflate (0.1 mol %) is a highly efficient catalyst for the cyclization of citronellal 1 , a reaction that yields a ratio of 80:20 of isopulegol 2 and neoisopulegol 3 . This methodology has also been extended to the synthesis of substituted piperidines. The bismuth triflate catalyzed ene reaction of aldehyde 4 gives a 70:30 mixture of piperidines 5 and 6 . The advantages of these methods include the use of a highly efficient catalyst that is relatively nontoxic, cheap and easy to handle.
Original languageAmerican English
JournalTetrahedron Letters
StatePublished - 2005


  • Bismuth and compounds; Carbonyl-ene reaction; Cyclizations; Lewis acids.


  • Organic Chemistry

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