Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.

Kristin Roederer; Loralyn Cozy; Jason Anderson; Justin P. Kumar

doi:10.1002/dvdy.20316

Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.

Kristin Roederer, Loralyn Cozy, Jason Anderson, Justin P. Kumar

Research output: Journal Article › Article › peer-review

Abstract

<div class="line" id="line-7"> The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant&hyphen;negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease. </div>

Original language	American English
Journal	Developmental Dynamics
Volume	232
DOIs	https://doi.org/10.1002/dvdy.20316
State	Published - Jan 3 2005
Externally published	Yes

Keywords

eye development
genes
mutations

Disciplines

Biology
Genetics
Anatomy

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10.1002/dvdy.20316License: Unspecified

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title = "Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.",

abstract = " The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant&hyphen;negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease. ",

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T1 - Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.

AU - Roederer, Kristin

AU - Cozy, Loralyn

AU - Anderson, Jason

AU - Kumar, Justin P.

N1 - The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis (so), the founding member of the Six gene ...

PY - 2005/1/3

Y1 - 2005/1/3

N2 - The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant&hyphen;negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease.

AB - The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant&hyphen;negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease.

KW - eye development

KW - genes

KW - mutations

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737192/

U2 - 10.1002/dvdy.20316

DO - 10.1002/dvdy.20316

M3 - Article

VL - 232

JO - Developmental Dynamics

JF - Developmental Dynamics

ER -

Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.

Abstract

Keywords

Disciplines

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