Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila.
- Kristin Roederer,
- ,
- Jason Anderson,
- Justin P. Kumar
- Indiana University Bloomington
Scholarship:
Journal Article
Article
Peer-reviewAbstract
The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant‐negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease.
Scholarship
Output type
Scholarship:
Journal Article
Article
Peer-reviewOriginal language
American EnglishJournal (Volume, Issue Number)
Developmental Dynamics (Volume 232)Publication milestones
- Published - 03/01/2005
Publication status
Published - 03/01/2005
Publication IDs
- Scopus: 14644415498
- PubMed: 15704100
Documents and links
License:Unspecified