The compressibilities of liquid phase host-guest systems

The compressibilities of seven liquid phase, macrocyclic host-guest systems were determined at approximately 25 °C and 3.4 × 10⁷ Pa. Each two-component system consisted of a cyclodextrin, a calixarene, or a crown ether as host and an appropriate solvent as guest. In each case studied, the host-guest system was found to be less compressible than the pure solvent, with the differences ranging from ∼2 to ∼ 18% of the magnitudes of the pure solvent compressibilities. These findings have enabled us to better understand how strong, ambient pressure, intermolecular host-guest interactions influence the compressibility of solutions. Both inclusion and solvation contribute.